Crk ELISA Kit for Rat(Rattus norvegicus) | EIAab.comCrk ELISA Kit for Rat(Rattus norvegicus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > Crk(Gene name) > Rat

Crk (Gene name),

Adapter molecule crk (Protein name ), CRK_RAT from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

Crk(Crko);

Protein name:

Adapter molecule crk;

Alternative:

p38;Proto-oncogene c-Crk;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with DOCK1, DOCK3, DOCK4, C3G and EPS15 via its SH3 domain. Interacts with SHB (By similarity). Interacts with PEAK1 (By similarity). Interacts with ABL1, C3G, SOS, MAP4K1, MAPK8 and DOCK1 via its first SH3 domain. Interacts with BCAR1, CBL, CBLB, PXN, IRS4 and GAB1 via its SH2 domain upon stimulus-induced tyrosine phosphorylation. Interacts with several tyrosine-phosphorylated growth factor receptors such as EGFR, PDGFR and INSR via its SH2 domain. Interacts with FASLG. Isoform Crk-II interacts with KIT. Interacts with EPHA3 (phosphorylated); mediates EFNA5-EPHA3 signaling through RHOA GTPase activation.

Function:

The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

Subcellular Location:

Cytoplasm Cell membrane Translocated to the plasma membrane upon cell adhesion.

Protein Attributes:

Sequence length:

304

Sequence:

50:

100:

150:

200:

250:

300:

304:

EDFS

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

String:

Q63768

KEGG:

rno:54245

Pfam:

PF00017

UniGene:

Rn.96136

SMR:

Q63768

STRING:

10116.ENSRNOP00000006407

Uniprot:

Q63768

FOR

ELISA Kit for Rat Adapter molecule crk

Cat.:

E9658m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Rat Adapter molecule crk

Cat.:

E9658h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Rat Adapter molecule crk

Cat.:

E9658r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Rat Adapter molecule crk

Cat.:

E9658c

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat Adapter molecule crk

Cat.:

U9658c

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat Adapter molecule crk

Cat.:

U9658r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat Adapter molecule crk

Cat.:

U9658h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat Adapter molecule crk

Cat.:

U9658m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Rat Adapter molecule crk

Cat.:

P9658Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Adapter molecule crk

Cat.:

P9658Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Adapter molecule crk

Cat.:

P9658Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Rat Adapter molecule crk

Protein for Rat Adapter molecule crk

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"CrkII signals from epidermal growth factor receptor to Ras."
Kizaka-Kondoh S. , Matsuda M. , Okayama H.
Proc. Natl. Acad. Sci. U.S.A.93:12177-12182(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Kidney.
2.

"Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling."
Abassi Y.A. , Vuori K.
EMBO J.21:4571-4582(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-221;MUTAGENESIS OF TYR-221

Product Feedback Wall

* Email:
*Comments: